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Kinematics and EMG

開催日 2014/9/11
時間 11:00 - 12:00
会場 Poster / Exhibition(Event Hall B)

Cerebral generator mechanisms of cortical tremor in patients with benign adult familial myoclonus epilepsy (BAFME): a corticomuscular coherence study

  • P1-117
  • 小林 勝哉 / Katsuya Kobayashi:1 人見 健文 / Takefumi Hitomi:2 松橋 眞生 / Masao Matsuhashi:3 櫻井 健世 / Takeyo Sakurai:1 松本 理器 / Riki Matsumoto:4 美馬 達哉 / Tatsuya Mima:3 福山 秀直 / Hidenao Fukuyama:3 加藤 昌明 / Masaaki Kato:5 関本 正規 / Masanori Sekimoto:5 大沼 悌一 / Teiichi Onuma:5 高橋 良輔 / Ryosuke Takahashi:1 池田 昭夫 / Akio Ikeda:4 
  • 1:京都大院・医・臨床神経学 / Dept Neurol, Kyoto Univ, Kyoto, Japan 2:京都大院・医・臨床病態検査学 / Dept Clin Lab Med, Kyoto Univ, Kyoto, Japan 3:京都大院・医・脳機能総合研究センター / Human Brain Res Center, Kyoto Univ, Kyoto, Japan 4:京都大院・医・てんかん・運動異常生理学 / Dept Epilepsy, Kyoto Univ, Kyoto, Japan 5:むさしの国分寺クリニック / Musashino-Kokubunji Clinic, Tokyo, Japan 

Introduction: Benign adult familial myoclonus epilepsy (BAFME) (Yasuda, 1991) is an autosomal dominant disease characterized by cortical tremor and infrequent generalized seizures. The precise pathological mechanism of cortical tremor (Ikeda et al., 1990) of BAFME is uncertain so far. We aimed to clarify the cerebral generator mechanism of cortical tremor in BAFME by means of corticomuscular coherence.
Methods: We employed 15 BAFME patients diagnosed based on clinical and electrophysiological findings (IRB #E1284). Electroencephalography (EEG), electromyography (EMG) and accelerometer were simultaneously recorded in all 15 patients. In addition, magnetoencephalography (MEG), EEG and EMG were also simultaneously recorded on different occasions in 3 patients. Patients were instructed to keep the hand with the outstretched posture in the air and also to do so with loading 500 g weight on the hand. Fourier Transform was applied for the frequency analysis. We compared the power spectrum between tasks to judge whether the tremor was of cerebral or peripheral origin.
Results: No significant corticomuscular coherence was observed at the frequency of cortical tremor in 12 patients. The frequency of significant corticomuscular coherence was consistent with that of peak power spectrum of cortical tremor in 2 patients. No significant coherence was observed in another patient.
Conclusion: The frequency of corticomuscular coherence and that of the peak of power spectrum did not show consistency in 12 out of 15 BAFME patients. Thus, the frequency of cortical tremor in BAFME could not be made directly by cerebral cortex but possibly modulated by other structures such as subcortical or cerebellum structures.

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