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Learning, Memory and Plasticity-2


開催日 2019/7/27
時間 14:20 - 15:20
会場 Room 9(3F 306+307)
Chairperson 麻生 能功 / Yoshinori Aso ( ジャネリア リサーチキャンパス / Janelia Research Campus )
喜田 聡 / Satoshi Kida ( 東京大学大学院農学生命科学研究科 / Graduate School of Agriculture and Life Sciences, The University of Tokyo )
  • 3O-09a1-2   Time: 14:35 - 14:50

Mnemonic rigidity revealed in macaques: A two-step mechanism underlying temporal-order judgement of naturalistic cinematic events

  • Zuo Shuzhen / Shuzhen Zuo:1 Wang Lei / Lei Wang:1 Shin Junghan / Junghan Shin:2 Cai Yudian / Yudian Cai:1 Jin Zhiyong / Zhiyong Jin:1 Sangwan Lee:3 Kusunoki Makoto / Makoto Kusunoki:4,5 Zhou Yongdi / Yongdi Zhou:1,7 Kwok SzeChai / SzeChai Kwok:1,6,7 
  • 1:Shanghai Key Laboratory of Brain Functional Genomics, Key Laboratory of Brain Functional Genomics Ministry of Education, School of Psychology and Cognitive Science, East China Normal University, Shanghai, China 2:Program of Brain and Cognitive Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea 3:Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea 4:MRC Cognition and Brain Sciences Unit, Cambridge, UK 5:Department of Experimental Psychology, University of Oxford, Oxford, UK 6:Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai, China 7:NYU-ECNU Institute of Brain and Cognitive Science at NYU Shanghai, Shanghai, China 

One important aspect of episodic memory is to remember the order in which events occurred. Previous studies have demonstrated that nonhuman primates possess the ability in making temporal order memory judgement. The underlying mechanism for retrieving episodic temporal information in macaque monkeys is however unclear. To address this question, we trained six macaque monkeys with a temporal order judgement (TOJ) task using naturalistic videos. In Experiment 1, monkeys performed 5000 TOJ trials with trial-unique videos. In each trial, they watched a video of about 10-s comprising two across-context clips and, after a 2-s retention delay, performed a temporal order judgement between two frames extracted from the video. We examined the effect of context shift by modelling the reaction time distributions in terms of threshold and information processing speed using the LATER (Linear Approach to Threshold with Ergodic Rate) model. The LATER results showed that context shifts accelerate the rate of accumulating information rather than by altering the decision-threshold for memory judgement, indicating their ability in detecting contextual change points in the stream of cinematic material. Moreover, regression analyses showed that monkeys responded significantly faster to frames that are extracted from earlier segments than those located at latter segments of the videos, suggesting that the monkeys may serially replay the videos in order to identify the target frame. This pattern of results was replicated with a new set of 8-s videos in Experiment 2, in which we systematically controlled for temporal similarity between conditions. Multi-unit activities are simultaneously recorded with semi-chronically implanted 32 independently movable microelectrodes (SC32, Gray Matter Research) in the medial posterior parietal cortex on two of the monkeys. We will present multi-unit activity and local field potential data in relation to how monkeys can segment episodic events in a coarse timescale like humans, as well as how they resort to inefficient serial-replay mechanisms when prominent temporal-contextual markers are absent during temporal-order retrieval.


研究助成:Research funds : Ministry of Education of PRC Humanities and Social Sciences Research grant 16YJC190006; STCSM Natural Science Foundation of Shanghai 16ZR1410200

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