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セッション名 学習・記憶・可塑性-1
Learning, Memory and Plasticity-2
開催日 2019/7/27
時間 14:20 - 15:20
会場 Room 9(3F 306+307)
Chairperson 麻生 能功 / Yoshinori Aso ( ジャネリア リサーチキャンパス / Janelia Research Campus )
喜田 聡 / Satoshi Kida ( 東京大学大学院農学生命科学研究科 / Graduate School of Agriculture and Life Sciences, The University of Tokyo )
  • 3O-09a1-1   Time: 14:20 - 14:35

Neurophysiology of hippocampus-independent memories in the macaque posterior parietal cortex

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  • Wang Lei / Lei Wang:1 Zuo Shuzhen / Shuzhen Zuo:1 Appiah Kofi / Kofi Appiah:2 Cai Yudian / Yudian Cai:1 Jin Zhiyong / Zhiyong Jin:1 Makoto Kusunoki:3,4 Zhou Yong-di / Yong-di Zhou:1,6 Kwok Sze Chai / Sze Chai Kwok:1,5,6 
  • 1:Shanghai Key Laboratory of Brain Functional Genomics, Key Laboratory of Brain Functional Genomics Ministry of Education, School of Psychology and Cognitive Science, East China Normal University, China 2:Department of Computing, Sheffield Hallam University, UK 3:MRC Cognition and Brain Sciences Unit, Cambridge, UK 4:Department of Experimental Psychology, University of Oxford, UK 5:Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, China 6:NYU-ECNU Institute of Brain and Cognitive Science at NYU Shanghai, China 

Recent fMRI studies on humans have revealed that rapid new memories formation is associated with BOLD activation and structural changes in the posterior parietal cortex, suggesting a hippocampus-independent neocortical memory engram (Brodt et al., PNAS, 2016; Brodt et al., Science, 2018). These cortices are also engaged as part of a social processing network that shows specific neural responses to viewing conspecifics in the macaques (Sliwa et al., Science, 2017). We then asked whether such experience-induced memories might contain content or behavioral-relevance specificity and how they might evolve over repetitive exposures (i.e., repetition suppression of complex experiences) during natural viewing. To address these questions, we recorded multi-unit neuronal activities using an array of 32-channal chronically implanted, independently movable micro-electrodes (SC32, Gray Matter Research) on two macaque monkeys while they underwent a natural viewing experiment. In each recording session, we had the macaques view three different videos each for 30 repetitions. We acquired neuronal data from 60 repetitions for each unique video (acquired across two consecutive days). In total, we used 18 unique videos and acquired data from 1080 video-viewing trials. The videos were all 30-s long and classified as either containing depiction of other primate animals, or depiction of non-primate animals, or of plain scenery (Category: primates/non-primates/scenery). We also manipulated contextual changes among the videos (Context: no boundary/one-boundary/two-boundary). The monkeys' eye movements during natural viewing were recorded at 240Hz by an iScan infrared eye-tracking system. In combination of convolutional neural network (CNN) models trained for object and feature classification, we used the oculomotor and spike data to classify parietal neurons by their selectivity to classes of visual contents and to verify the repetition suppression phenomenon during memory formation. These results help elucidate the neurophysiological basis of the recently discovered hippocampus-independent neocortical memory engram in the primates.

 

研究助成:Research funds : Ministry of Education of PRC Humanities and Social Sciences Research grant 16YJC190006; STCSM Natural Science Foundation of Shanghai 16ZR1410200

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